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HL-A Antigens in Thromboangiitis Obliterans

Toshiyuki Ohtawa, MD; Takeo Juji, MD; Nobuhiro Kawano, MD; Yoshio Mishima, MD; Hiroshi TOHYAMA, MD; KOICHI ISHIKAWA, MD
JAMA. 1974;230(8):1128. doi:10.1001/jama.1974.03240080018015.
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To the Editor.—  We have recently observed that the frequency of occurrence of a particular second sublocus group HL-A antigen (tentatively specified by us as J-1-1) was significantly higher (P <.001) in Japanese patients with thromboangiitis obliterans (TAO) than it was in a population of normal Japanese. As shown in the Table, J-1-1 antigen was found in 46% of the TAO patients, relative to a normal population occurrence of 18%.Also, antigens HL-A9 and W10 showed an increased occurrence in TAO patients. However, antigen HL-A12 was not found in TAO patients, but it occurred with a frequency of 20% in the normal population.The Figure illustrates our classification of the J-1-1 antigen.In our study, 11 antisera from pregnant Japanese women showed a very high correlation with each other in their reactivities on the lymphocytotoxicity test (LCT), using normal Japanese panel lymphocytes. With the LCT test antisera, the antigen that


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