We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

"Owl Eye" Sign of Benign Autonomous Thyroid Nodule

FUAD S. ASHKAR, MD; William M. Smoak III, MD
JAMA. 1970;214(8):1563. doi:10.1001/jama.1970.03180080143030.
Text Size: A A A
Published online


To the Editor.—  In 1913, Plummer differentiated diffuse toxic goiter from toxic autonomous nodular goiter on the basis of observation on 2,000 patients who underwent operations.1 The autonomous nodular goiter presents a special diagnostic problem in its toxic and pretoxic stages, because of the existence in it of inactive thyroid tissue that gives a "cold" appearance in the scintigram. The nodules are variable in size, most of them are larger than the surrounding suppressed normal tissue, and in cross section represent a group of variable-sized, functioning follicles.2 Functional capacity of these autonomous nodules is limited in comparison to diffuse toxic disease, toxicity is only produced after a dimension of three to four cm is reached.2,3A new area of suppressed function was noted by our group in the autonomous nodular goiter; it occurs usually in a central position in the autonomous nodule (Fig 1 and 2). This


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.