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Apnea After Intravenous Diazepam

G. David Dixon, MD
JAMA. 1978;239(4):294. doi:10.1001/jama.1978.03280310026005.
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To the Editor. —  The article entitled "Apnea After Intravenous Diazepam Therapy" by Hall and Ovassapian (238:1052, 1977) emphasizes an important complication.They report using a 10-mg bolus intravenously for treatment of the patient's anxiety. A bolus injection to me generally means rapid intravenous injection. The product information sheet accompanying Valium emphasizes the importance of slow intravenous injection (5 mg/min). I use this drug frequently during angiography for the same indication. I believe it is important to use slow intravenous administration since frequently a patient will become very sedated with obvious slowing of the respirations with less than 10 mg.By using slow intravenous administration, the patient's condition can be monitored, and overdosage with the resultant complications can be avoided.


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