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Primary Type V Hyperlipoproteinemia in Childhood

Daniel Yeshurun, MD; Hong Chung, PhD; Antonio M. Gotto Jr, MD, DPhil; O. David Taunton, MD
JAMA. 1977;238(23):2518-2520. doi:10.1001/jama.1977.03280240064023.
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Metabolic studies of a 9-year-old girl with primary type V hyperlipoproteinemia demonstrated normal glucose tolerance, plasma insulin and glucagon responses to stimuli, and serum uric acid level. Fasting plasma triglyceride levels rapidly increased when the patient received a diet containing 40% of the total calories as fat and rapidly decreased on a 10% fat diet. Hepatic and nonhepatic lipase activities in postheparin plasma were normal, thus excluding type I hyperlipoproteinemia. Because of the potential complication of acute pancreatitis in this disorder, early diagnosis and prompt institution of diet therapy is important.

(JAMA 238:2518-2520, 1977)


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