Accuracy of Clinical Blood Gas Measurements

John W. Brantigan, MD
JAMA. 1974;229(13):1723. doi:10.1001/jama.1974.03230510015009.
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To the Editor.—  In the development of catheters for continuous measurement of blood gases by mass spectrometry (J Appl Physiol 28:375-377, 1970; 32:276-282, 1972), it has been necessary to compare data with results of analyses by ordinary instruments that do not provide an absolute standard. In order to assess the accuracy of clinical blood gas measurements, a study was done in dogs in which split samples of arterial blood were analyzed on four separate instruments of three independent institutions.A dog weighing 20 kg (44 lb) was anesthetized with pentobarbital sodium (25 mg/kg) and placed on a respirator. The femoral artery was cannulated percutaneously and a Teflon catheter inserted for continuous measurement of blood gases by mass spectrometry. A Y-piece allowed withdrawal of arterial blood samples through the same puncture site. When the spectrometer indicated stable blood gas levels, split samples of arterial blood were obtained in heparinized glass syringes


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