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Sex Chromatin in Women With Breast Cancer, Leukemia, Lymphoma, and Hypertension

Alex S. D. Spiers, MD; J. E. Turner, MD
JAMA. 1977;238(17):1812-1813. doi:10.1001/jama.1977.03280180016009.
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To the Editor.—  Some constitutional disorders associated with aneuploidy and other cytogenetic defects carry an increased risk of neoplastic disease.1 Numerical abnormality of the sex chromosomes, the commonest constitutional aneuploidy in adults, is no exception. The XXY Klinefelter's syndrome is associated with an enhanced risk of leukemia, lymphoma, and breast cancer,2 and the XO Turner's syndrome may have an association with leukemia. The XXX syndrome may be associated with an increased liability to mental illness,3 and the coexistence of X-trisomy and Hodgkin's disease has been observed,4 but there does not seem to be an overall increased incidence of cancer in XXX women. A survey of 8,600 consecutive hospital admissions disclosed seven XXY men and three XXX women but showed no new disease associations of X chromosome abnormalities: one XXY man had carcinomatosis with an unknown primary tumor.5By staining the nuclei of buccal mucosal cells


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