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Fixed-Dose Combinations of Drugs

JAMA. 1970;213(7):1172-1175. doi:10.1001/jama.1970.03170330054008.
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In view of the considerable publicity surrounding the use of fixed-dose combinations of drugs, the Council on Drugs has reexamined the place of such products in rational therapeutics and believes that a restatement of its attitude on this kind of drug is in order.

Throughout its many years, the Council has maintained a consistent attitude concerning fixed-dose combinations. This attitude was expressed by this statement in the 1909 edition of the Council's publication, New and Nonofficial Remedies (NNR):

For admission to NNR, proprietary pharmaceutical mixtures must comply with the rules [of the Council], and to determine such compliance, they will be investigated by the Council. The Council, however, endorses the principle that prescriptions should be written on the basis of the therapeutic effects of the individual ingredients. For this reason, it includes in this book only those mixtures that present some real advantage.

In later editions of NNR, a similar,


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