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Ménétrier's Disease Diagnosed by Electrosurgical Snare Biopsy

John T. Bjork, MD; Joseph E. Geenen, MD; Richard A. Komorowski, MD; Konrad H. Soergel, MD
JAMA. 1977;238(16):1755-1756. doi:10.1001/jama.1977.03280170049027.
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MÉNÉTRIER'S disease is traditionally diagnosed by full-thickness gastric biopsy specimens obtained at exploratory laparotomy or at autopsy. This is necessary because standard endoscopic mucosal biopsies yield material that is too small and thin to evaluate mucosal thickness, and thus are inadequate to diagnose hyperplastic mucosal lesions. This case report describes a patient with Ménétrier's disease diagnosed by full-thickness endoscopic mucosal biopsy1-3 and who was therefore spared exploratory surgery.

Report of a Case  A 48-year-old minister had a five-year history of nonspecific gastrointestinal symptoms. He had lost 18 kg in weight during the past six months. He denied abdominal pain, early satiety, change in bowel habits, excessive alcohol or aspirin intake, but complained of occasional nausea, vomiting, and anorexia. Past medical and family history was unremarkable.Physical examination showed a thin, 57.1-kg man with normal vital signs. Pertinent negative findings included the absence of ascites, organomegaly, abdominal masses, and peripheral


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