To the Editor.—
A patient of mine with skin biopsy-proven scleroderma reports an interesting observation. During the summer of 1973, when there was a heavy influx of mosquitos in her section of Queens, NY, she alone, among her family and friends, was totally immune from mosquito bites.Of further interest is her family history: Her sister and mother both have the Ehlers-Danlos syndrome, with hyperelastic skin, hyperextendable joints, bossing of the skull, and "cigaret-paper" scars of the knees and forehead. Her mother is the offspring of a first-cousin marriage. Karyotyping of all three individuals failed to reveal any gross chromosomal abnormalities.