Subcutaneous Rheumatoid Nodules and Serum Rheumatoid Factor Without Arthritis

Ali Askari, MD; Roland W. Moskowitz, MD; Victor M. Goldberg, MD
JAMA. 1974;229(3):319-320. doi:10.1001/jama.1974.03230410043024.
Text Size: A A A
Published online

SUBCUTANEOUS rheumatoid nodules and serum rheumatoid factor are diagnostic criteria of definite or classic rheumatoid arthritis. They are generally associated with chronic deforming arthritis and severe systemic manifestations of rheumatoid disease. The titer of rheumatoid factor usually parallels disease severity.

This study describes a patient with multiple large subcutaneous rheumatoid nodules and high-titer serum rheumatoid factor without arthritis.

Report of a Case  A 56-year-old white man was admitted to University Hospitals of Cleveland on May 25, 1973, with the complaint of lumps in the area of both elbows for five years. These growths first appeared on the left and later on the right elbow as pea-sized growths. The swellings were painless and did not ulcerate or interfere with elbow function. The nodules grew larger and coalesced during the subsequent five years.Medical history disclosed an attack of polyarthralgias without actual swelling 12 years prior to hospital admission. Symptoms were completely


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours




Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.