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Renal Histopathology: A Light Microscopy Study of Renal Disease

Cecil A. Krakower, MD
JAMA. 1974;229(1):84-85. doi:10.1001/jama.1974.03230390060037.
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Large medical centers have nephrology units that are fully equipped and manned to perform electron microscopy and immunofluorescence, two of the important present-day techniques used to supplement light microscopy in the diagnosis of renal disease. There are, however, many hospitals that are not so endowed. For the pathologists and nephrologists of such hospitals, this text should be a welcome one. It lays down the principles on which faithful light microscopic readings may be made. These include the use of very thin paraffin sections (2μ thick) and a limited number of highly useful stains such as PAS, acid fuchsin, and its combination with methenamine silver. It emphasizes the importance of a knowledge of electron microscopic findings in the different renal diseases as a basis for interpreting the light microscopic findings. It provides superb photomicrographs illustrative of these diseases. With these prerequisites and with the text as a visual aid, a high


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