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Congenital Dyserythropoietic Anemia In Jews From Morocco

A. Berrebi, MD; P. Efrati, MD
JAMA. 1974;229(1):24. doi:10.1001/jama.1974.03230390016008.
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To the Editor.—  During the last three months, seven cases of congenital dyserythropoietic anemia (CDA) type 2 (HEMPAS) have been diagnosed in our hospital. Of these, three cases were diagnosed in retrospect in patients who had been splenectomized two, four, and six years ago for chronic hemolytic anemia with splenomegaly. In all cases, the diagnosis was confirmed by a positive acidifiedserum test and an agglutination of the erythrocytes with an anti-i-serum. Bone marrow examination was performed in five cases, and the typical picture of multinucleated normoblasts and Gaucher-like cells was found. This examination has not yet been performed in two cases. Three pairs of siblings are affected.Two or more siblings affected in the same family is not rare, and has been reported by other authors.1,2 Our most important observation is that all the patients' country of origin is Morocco. In addition to our observation, we obtained the information


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