0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Minimal Effective Dosage of Cromolyn

Stanley Hoyt Block, MD
JAMA. 1974;229(1):22. doi:10.1001/jama.1974.03230390014003.
Text Size: A A A
Published online

To the Editor.—  Numerous studies have shown that cromolyn sodium is an effective antiasthmatic medicine when used prophylactically on a regular basis. Cromolyn inhibits the degranulation of sensitized mast cells that occurs after exposure to specific antigens, and inhibits the release of histamine and SRS-A. The manufacturers of cromolyn, and investigators, advise a starting dose of 20 mg (one capsule) four times a day by inhalation, for children 5 years old and over.1 The manufacturers' brochures state that "the dose for adults and children 5 and over is the contents of one Aarane capsule inhaled four times daily at regular intervals...." Dykes2 specifies the minimum dosage that is found effective. For this reason, the following case illustrates an important point.

Report of a Case.—  A 5-year-old white boy gave a three-year history of asthma, and had been wheezing almost daily for two years. His wheezing increased with exercise.

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Figures

Tables

References

Letters

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

* * SCHEDULED MAINTENANCE * *

Our websites may be periodically unavailable between midnight and 04:00 ET Thursday, July 10th, for regularly scheduled maintenance.

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();