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Familial Urinary Tract Anomalies

Jo Leigh Simpson, MD; James German, MD
JAMA. 1970;212(13):2264-2265. doi:10.1001/jama.1970.03170260060020.
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To the Editor.—  Familial occurrence of a given disorder may provide the first indication that genetic factors are of importance in its etiology. Our purposes here are (1) to provide the references to previously published reports concerning the uropathies and anomalies of the ureters and bladder and (2) to record some personal observations of familial urinary tract anomalies, thus, raising a question concerning the possible importance of heredity in this group of disorders.Hydronephrosis without hydroureters, suggesting uretero-pelvic junction obstruction, has been observed in sibs1 and in two2,3 and three4,5 generations of families; in two1,3 of these families aberrant renal vessels were described. Hydronephrosis accompanied by hydroureters,6 ureterocele,7 bladder neck obstruction,8 or posterior urethral valves9,10 has occurred in sibs or twins. Familial occurrence of ectopic ureteral insertion11 and duplication of the collecting system2,12-15 have also been observed. Lenz2 refers


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