We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......

Treatment of Gilles de la Tourette Syndrome

Arthur K. Shapiro, MD; Elaine Shapiro, PhD
JAMA. 1977;238(1):29. doi:10.1001/jama.1977.03280010029012.
Text Size: A A A
Published online


To the Editor.—  Based on study of and experience with more than 450 patients and treatment of more than 250 patients with Gilles de la Tourette syndrome,1 we have identified a group of patients who can be successfully treated only if the dosage of haloperidol is titrated very slowly, perhaps in increments of 0.25 mg/day every three weeks. This slow treatment method grew out of several observations during our treatment of patients. Some patients elected to or found it necessary to discontinue administration of the medicine because of side effects. Tic symptoms usually return and side effects usually disappear four days after stopping administration of the medicine. In some patients the tic symptoms did not fully reappear after discontinuing treatment with haloperidol for at least three weeks, and side effects from the medicine persisted for three weeks.These clinical observations suggest the hypothesis that patients who discontinue treatment with


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.