Colon Carcinoma and the Cancer Family Syndrome

Rolf D. Arndt, MD; Robert J. Kositchek, MD; Peter D. Boasberg, MD
JAMA. 1977;237(26):2847-2848. doi:10.1001/jama.1977.03270530055026.
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THE CONCEPT of "cancer families" was first introduced in the early part of this century and refers to those kindreds with a high incidence and early onset of adenocarcinoma in various organs, but particularly the colon. The incidence of adenocarcinoma of the colon is well recognized to be increased in familial syndromes associated with colon polyps. Recently, however, a prevalence of this carcinoma without colonic polyps has been described in families.1

We have observed carcinoma of the colon in a mother and a daughter and an adenomatous polyp in the son. All occurred at an early age and were located in essentially the same region of the large bowel.

Report of a Case  The mother is a 54-year-old woman hospitalized in January 1974 at St John's Hospital and Health Center, Santa Monica, Calif, with sudden onset of abdominal pain and fever. Barium enema examination showed a 2.5-cm annular mass


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