Residual Abnormalities in Acquired Aplastic Anemia of Childhood

Melvin H. Freedman, MD, FRCP(C); E. Fred Saunders, MD, FRCP; James Hilton, MD; Peter D. McClure, CM, MD, FRCP(C)
JAMA. 1974;228(2):201-202. doi:10.1001/jama.1974.03230270045026.
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WITH improvements in supportive care, approximately 50% of children with acquired aplastic anemia (AAA) now survive their disease.1 Little reference is made in either standard textbooks or in the medical literature regarding persisting hematologic abnormalities in these patients. We have observed and studied the survivors of AAA whose conditions were diagnosed in our institution and none was hematologically normal, indicating that hematologic residua last for years, and perhaps a lifetime.

Patients and Methods  Twenty-three children with AAA were hospitalized between 1962 and 1972. In 18, there were no known associated diseases or precipitating factors. In two, the anemia followed hepatitis, and in three it followed chloramphenicol administration. Standard criteria for diagnosis were used.2There were ten survivors of whom four boys and four girls were available for reassessment after one to nine years from the time of diagnosis. In one of the survivors AAA developed following chloramphenicol administration;


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