0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Widened Cranial Sutures in Metastatic Neuroblastoma

Carl Pochedly, MD; Godratollah Sarrafi, MD; Joan B. Dobbs, MD
JAMA. 1974;227(6):659. doi:10.1001/jama.1974.03230190051023.
Text Size: A A A
Published online

To the Editor.—  Enlargement of the head and widening of the cranial sutures are fairly common complications of metastatic neuroblastoma. The cause is not clearly understood. We recently observed these signs in a child with a rapidly progressive tumor.

Report of a Case.—  An 18-month-old girl with persistent fever and vomiting developed an ear infection, treated with antibiotics. Examination three and a half weeks later showed ecchymosis of the left upper eyelid, and a large mass in the left side of the abdomen extending to the iliac crest. The hemoglobin level was 6.5 gm/100 ml; hematocrit reading, 22%. A bone marrow aspiration showed tumor cells. Serum alkaline phosphatase, lactic dehydrogenase, and serum glutamic oxaloacetic transaminase levels were all markedly elevated. A large mass (shown by intravenous pyelogram) displaced the left kidney laterally and inferiorly. Osteolytic lesions appeared in both lower femurs, and skull roentgenogram showed slight separation of the cranial

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Figures

Tables

References

Letters

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();