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Birth Defects in Child of Male Recipient of Kidney Transplant

Marion B. Tallent, MD; Richard L. Simmons, MD; John S. Najarian, MD
JAMA. 1970;211(11):1854-1855. doi:10.1001/jama.1970.03170110060018.
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To the Editor:—  Reports of normal children being born to kidney transplant recipients, who were receiving long-term immunosuppressive therapy, have been made.1-3 However, to our knowledge, this is the first report of the birth of an abnormal infant whose father had such a transplant.

Report of a Case.—  A female infant, born on March 22, 1969, was immediately transferred to the University of Minnesota Hospitals because of multiple deformities noted at birth. She was the product of an uncomplicated full-term pregnancy.The infant had one maternal uncle with a congenital hearing defect.The mother had taken no drugs during pregnancy. She had had five previous pregnancies, all more than five years earlier, the fourth of which ended in a first-trimester spontaneous abortion. The other children are all living and healthy. This was her first pregnancy since her husband had received a kidney allotransplantation.The father had undergone renal transplantation

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