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Kenneth M. Brinkhous, MD
JAMA. 1973;226(9):1124. doi:10.1001/jama.1973.03230090048026.
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Hemophilia has received increasing attention from physicians, dentists, and biomedial scientists, on a worldwide basis, since the advent of replacement therapy with plasma fractions to control hemorrhagic episodes. The many avenues open for the study and management of hemophilia are reflected in this volume which consists of a series of essays, 48 in all, presented at an international hemophilia congress in Tehran in 1971. The major topics covered are the following: regulation of the anti-hemophilic factor (factor VIII), genetic variants in congenital disorders of coagulation, the pathophysiology of hemostasis, blood transfusion and plasma fractionation, orthopedic aspects of hemophilia, dental aspects of hemophilia, and current trends in hemophilia treatment. Most of the reports deal with hemophilia A. The status of organ transplantation, especially liver transplants, blood banking procedures, and the diagnosis and treatment of inhibitor hemophilia are well covered. A sober evaluation of synovectomy for treating crippling hemarthropathy suggests its main


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