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ARTICLE |

Spotlight on Antimicrobial Agents—1973

Benjamin M. Kagan, MD; Shirley L. Fannin, MD; Felix Bardie, MD
JAMA. 1973;226(3):306-310. doi:10.1001/jama.1973.03230030026007.
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This is one of several articles sponsored by the American Society for Clinical Pharmacology and Therapeutics. The goals are as follows: (1) maximally effective drug therapy, (2) reduction of the incidence of serious adverse drug reactions, and (3) maximum effectiveness and safety at the lowest cost for the patient.

To accomplish the goals set forth with antimicrobial agents, it is necesssary that the physician have a basic understanding of the constantly changing relationships between microbes, the human host, and antimicrobial agents.1

Both microbes and humans are in a constant state of change. The growth rates of microbes and their degrees of susceptibility to antimicrobial agents may change via a number of different mechanisms. For instance, during a single course of therapy a microbe may become resistant to the antimicrobial agent by (1) emergence of genotypic drug resistance or (2) transfer of resistant factor (R) or (3) alterations in microbe

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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