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December 22, 1969, Vol 210, No. 12 >
ARTICLE | December 22, 1969

Serum Zinc Level in Diabetes

C. S. Reusch, MD; Leitha D. Bunch, MA
JAMA. 1969;210(12):2285. doi:10.1001/jama.1969.03160380099032.
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To the Editor:—  That a relationship could exist between zinc and insulin has been suspected since the crystallization of a zinc-insulin complex. It cannot be determined from physiological evidence if an insulin-zinc complex is necessary for biological activity.1 It is now known that insulin can be crystallized by metals other than zinc.2Prout et al3 in 1960 made a study of plasma zinc concentration in patients with diabetes. They found no significant relationship between plasma zinc concentration and the insulin requirement of the diabetic patients.We have measured the serum zinc concentration in a series of patients receiving different orally administered hypoglycemic agents and in healthy control subjects. Zinc was measured by the atomic absorption spectrophotometer.

Results:—  In healthy control subjects, the zinc content of serum in 53 healthy males and 56 healthy females was not significantly different. The observed range of zinc of the combined males

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