We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Mild Hypertension and Antihypertensive Drugs

S.K. Robinson, MD
JAMA. 1973;225(10):1247-1248. doi:10.1001/jama.1973.03220380059021.
Text Size: A A A
Published online


To the Editor.—  The report on a 51-year-old black woman who died of hepatic necrosis after taking methyldopa (224:1390, 1973) should make us take a hard look at the dangers of antihypertensive drugs. The authors state: "The drug is well tolerated in most cases."Sheps et al had shown major side effects in 30% and advised against the use of methyldopa.1 As many as 35% of patients may show liver damage with methyldopa.2 Hoyumpa et al3 reported three cases of hepatitis—two were severe and one patient died. Raftos (Med J Aust 2:837, 1967), using methyldopa, had 63 cases of toxic reaction with eight deaths in 14 months, which is every high; two deaths occurred after drug withdrawal. This phenomenon of a cerebrovascular accident shortly after drug withdrawal was observed several times by Hood et al and may be drug-related.4 Two thirds had severe side effects consisting of


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.