LSD, Alcohol, and Homicide

Robert L. Sadoff, MD
JAMA. 1973;225(9):1123. doi:10.1001/jama.1973.03220370061030.
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To the Editor.—  It has now come to my attention in two dramatic cases, both involving homicide, that alcohol ingestion following a series of LSD "trips" may have a stimulating effect on the "flashback" phenomena. In both cases, the individuals had had a number of experiences with LSD, with rarely an unfavorable reaction. Several months after the discontinuance of the LSD ingestion, but with increased alcohol intake, hallucinatory experiences of the "flashback" variety continued. In both instances the alcohol precipitated a psychotic reaction with hallucinations and delusions directly related to the violent behavior and consequent homicide.In one case I introduced alcohol in a controlled test dose. I administered 95% ethyl alcohol mixed in a 3:1 solution with fruit juice. After 63 ml of the alcohol was ingested, the patient noted visual distortions characteristic of LSD intake, but not characteristic of alcohol intoxication. After 125 ml of alcohol was ingested,


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