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November 17, 1969, Vol 210, No. 7 >
ARTICLE | November 17, 1969

MEDICAL NEWS

JAMA. 1969;210(7):1181-1192. doi:10.1001/jama.1969.03160330007003.
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ABSTRACT

'The Average Penicillin Allergy Is Not An Allergy  '"Allergic to penicillin" was boldly splashed in red across the clinic record. Seemingly oblivious to the warning, the physician told the 6-year-old boy with "strep throat" that the shot would hurt for only a few moments, and then injected 1,200,000 units of benzathine penicillin.Recovery from "strep throat" was noted within 24 hours, and no adverse effects of penicillin were observed.The little boy was one of 208 children with Beta-hemolytic streptococcal infections (Group A). All had a history of penicillin sensitivity noted in their record, but the basis for the notation was a macular rash, hives, or minor symptoms. The children were selected for study at Travis Air Force Base, Calif.Children with a history of severe edema or airway obstruction following previous penicillin administration were not included in the series.Each child was given penicillin but only one child in

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