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November 3, 1969, Vol 210, No. 5 >
ARTICLE | November 3, 1969

Chlorpropamide-Induced Hypoglycemia in a Child With Diabetes Insipidus

Lawrence R. Kuhns, MD; Martha L. Spencer, MD; George E. Bacon, MD; George H. Lowrey, MD
JAMA. 1969;210(5):907. doi:10.1001/jama.1969.03160310095030.
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To the Editor:—  A recent discussion of diabetes insipidus1 indicated that experience to date is limited as to whether or not treatment with chlorpropamide involves a significant hazard from hypoglycemia. The following case report emphasizes the possible dangers of this drug in patients with diabetes insipidus.

Report of a Case:—  An 11-year-old girl weighing 29 kg (64 lb) had had a craniopharyngioma which was partially removed at the age of 5 years. The patient did well postoperatively except for poor vision secondary to optic nerve damage. Maintenance therapy consisted of thyroid extract, 0.09 gm daily; prednisone, 3 mg daily in divided doses, and vasopressin (Pitressin) tannate in oil, 1 ml every two days. She had been on a similar regimen for six years. During a routine outpatient visit, chlorpropamide treatment, 250 mg twice daily was instituted in an attempt to eliminate the need for vasopressin injections. During the next

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