Precipitation of Diazepam From Intravenous Preparations

William J. Jusko, PhD; Mark Gretch; Robert Gassett, MS
JAMA. 1973;225(2):176. doi:10.1001/jama.1973.03220290054019.
Text Size: A A A
Published online


To the Editor.—  The recent article by Langdon et al in The Journal (223:184, 1973) described the 3.5% incidence of thrombophlebitis that occurs when diazepam (Valium) is given intravenously. Precipitation of the relatively water-insoluble diazepam may account for this problem.Studies of the precipitation of diazepam were prompted by our observation that this product was frequently administered by injection through the tubing of an intravenous infusion set, rather than directly into the patient. This is contrary to the warning of the manufacturer who stated in the package insert that: "When used intravenously the solution should be injected slowly, directly into the vein, taking at least one minute for each 5 mg (1 ml) given. Do not add to I.V. fluids." The limited aqueous solubility of diazepam necessitates its formulation into a solution containing propylene glycol (40%) and alcohol (10%), buffered with benzoate sodium and benzoic acid (5%), and preserved with benzyl


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours




Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.