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Article |

Classification of Primary Hyperlipidemia Observations on 214 Patients

Irwin J. Schatz, MD
JAMA. 1969;210(4):701-704. doi:10.1001/jama.1969.03160300041008.
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Classification of the hyperlipoproteinemias permits a rational approach to the diagnosis and management of these conditions. This study included 214 patients with primary hyperlipidemia. The Fredrickson-Lees criteria were used. There were no type 1 cases, 75 type 2, 12 type 3, 71 type 4, 12 type 5, and 44 unclassifiable. Abnormal responses to glucose tolerance tests occurred in 3 of 23 patients with type 2 and 52 of 54 patients with types 3, 4, and 5 disease. Most cases may be classified successfully if the patient's clinical history, fasting serum cholesterol and triglyceride levels, and serum lactescence are known; in this group, the omission of lipoprotein electrophoresis altered classification in no type 2, six type 3, and four type 4 patients.


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