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October 20, 1969, Vol 210, No. 3 >
ARTICLE | October 20, 1969

Subacute Sclerosing Panencephalitis

Michael Katz, MD; Lucy Balian Rorke, MD
JAMA. 1969;210(3):559. doi:10.1001/jama.1969.03160290111044.
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ABSTRACT

To the Editor:—  J. T. Jabbour et al in "Subacute Sclerosing Panencephalitis" (207:2248, 1969), report their failure to transmit encephalitis to ferrets by intracerebral injection of brain material obtained by biopsy of patients with subacute sclerosing panencephalitis (SSPE). They contrast this failure with our success in achieving such a transmission (New Eng J Med279:793 1968). Before this discrepancy in results can be evaluated, it would be necessary to establish whether the method Jabbour and his co-workers used was comparable to ours. The authors have not explained the details of their technique, nor have they stated what kind and amount of inoculum they used, or how long they observed the animals before killing them.The authors state that the histologic changes and type of inclusion bodies in their patients were classical for SSPE, being characterized by astrocytic gliosis and perivascular cuffing; in two of the patients, in addition,

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