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Esophageal Cancer, Hyperkeratosis, and Oral Leukoplakia: Follow-up Family Study

Samuel B. Ritter, MD; Glen Petersen, MD
JAMA. 1976;236(16):1844-1845. doi:10.1001/jama.1976.03270170010009.
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To the Editor.—  The incidence of cancer of the esophagus and tylosis (palmaplantar keratoderma) has previously been reported in a number of families1,2 as well as its association with oral leukoplakia.3 We have recently reported a case of esophageal 58 35 8 5 4 1 50 33 31 25 11 7 5 3 23 18 5 4 2 16 14 6 5 3 2 Male Female Tylosis Normal 6 4 3 1 Tylosis Tylosis, Leukoplakia Leukoplakia, Esophageal Cancer Fig 1.—Family tree with ages. cancer associated with hyperkeratosis and oral leukoplakia in a 25-year-old woman with a family history of tylosis.4 This is the follow-up study of that family.The patient's family consisted of parents, her children, and seven siblings and their children. A medical history, stressing gastrointestinal symptoms, was taken from each member and a physical examination performed. The results are shown in Fig 1.The onset


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