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Methyl Methacrylate

Nicholas L. Schenck, MD
JAMA. 1976;236(15):1694. doi:10.1001/jama.1976.03270160018018.
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To the Editor.—  "Hazard of Methyl Methacrylate to Operating Room Personnel" (235:2652,1976) focused on the problem of allergenic sensitization. In a recent investigation to find a suitable alternative material for frontal cranioplasty, we had the occasion to review other potential disadvantages of this widely used alloplastic material.1First, it is difficult to handle in the operating theater because of heat produced during the exothermic mixing process. Second, malleability is absent after it sets. Third, most surgeons are loathe to place the acrylic at a primary procedure because of potential infection, necessitating a temporary cosmetic deformity and a subsequent trip to surgery for eventual reconstruction. Fourth, the plastic implant is vulnerable to trauma with resulting fragmentation and, in certain cases, brain injury.2 Cranioplast can also diffuse through intact surgical rubber gloves and cause contact dermatitis.3Hence, methyl methacrylate, one of the most valuable and widely used alloplastic surgical


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