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Activity of Daunomycin in Solid Tumors

Daniel D. Von Hoff, MD; Marcel Rozencweig, MD; Milan Slavik, MD, PhD; Franco M. Muggia, MD
JAMA. 1976;236(15):1693. doi:10.1001/jama.1976.03270160017015.
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To the Editor.—  In the concise review of the cardiac effects of doxorubicin hydrochloride (Adriamycin) by Ugoretz (236:295, 1976), it was stated that daunomycin does not have as wide a spectrum of antitumor activity as dexorubicin. This point is a commonly held misconception and has been perpetuated in other publications.1The results of a recent review performed by the Investigational Drug Branch of the National Cancer Institute on the activity of daunomycin in solid tumors are shown in the Table. It is apparent from the Table that there has been only a small number of patients treated with daunomycin in each solid tumor category. Not one of the solid tumors has had an adequate trial with daunomycin in a single study.In reality, then, we do not have enough information to actually say whether daunomycin is active or inactive in solid tumors. With this lack of a data base


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