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Sept 22, 1969, Vol 209, No. 12 >
ARTICLE | Sept 22, 1969

Determination of Brain Death by Isotope Angiography

Julius M. Goodman, MD; Fred S. Mishkin, MD; Mark Dyken, MD
JAMA. 1969;209(12):1869-1872. doi:10.1001/jama.1969.03160250025005.
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In more than 500 studies of cerebral perfusion by isotope angiography with the scintillation camera, visualization of cerebral arteries and venous sinuses invariably occurred, except in the three patients studied with suspected brain death. Each of these patients was deeply comatose, with dilated, fixed pupils, and required artificial ventilation. At autopsy their brains had severe autolytic changes (respirator brain). This preliminary experience suggests that an isotope angiogram showing no evidence of cerebral vasculature would be valuable in corroborating the clinical impression of brain death.

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