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August 25, 1969, Vol 209, No. 8 >

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ARTICLE | August 25, 1969

Parotid Gland Swelling Due to Methimazole

Robert C. Moehlig, MD
JAMA. 1969;209(8):1224. doi:10.1001/jama.1969.03160210056021.
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ABSTRACT

To the Editor:—  To the best of my knowledge, the swelling of the parotid gland due to methimazole (Tapazole) has not been reported in the literature and the manufacturer does not list this as one of the side effects. I wish, therefore, to report the following case:A 62-year-old woman with hyperthyroidism had been under the care of an allergist. On March 11, 1969, the patient was treated with methimazole, 10 mg every eight hours. Reactions to methimazole were explained to her.On April 29, the patient thought she had mumps; this involved both parotid glands. She was told to discontinue methimazole and within three days the swelling disappeared. On May 4, the patient took one methimazole tablet and the swelling of the parotids reappeared within a few hours.The relationship between the salivary glands and the thyroid is of course known. Hammett found the development of the submaxillary glands

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