Rapidly Progressive Dyspnea in a Teenage Boy

Averill A. Liebow, MD; Kenneth M. Moser, MD; M. Therese Southgate, MD
JAMA. 1973;223(11):1243-1253. doi:10.1001/jama.1973.03220110025008.
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[Protocol]  A 15-year-old white boy first noted some mild dyspnea in the summer of 1963, while riding his bicycle. At that time he lived in Massachusetts. No cause for the dyspnea was apparent, but it was progressive until, during the following winter, he developed a "cold" with dry cough and had to be hospitalized because of marked dyspnea. He was treated for pneumonia with right pleural effusion. Shortly thereafter the family moved to Florida, and the boy was hospitalized at Fort Myers in late March because of increasing dyspnea as well as the onset of cyanosis. He also had marked fatigue and some weight loss with vomiting during the few days immediately preceding hospitalization.The history disclosed that the boy had had prolonged colds each winter accompanied by wheezing, and that for several years he had been intermittently exposed to chickens on a neighbor's farm. No history was obtained of


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