Atypical Reaction to Isoproterenol

James Warth, MD; Arnold Rappaport, MD
JAMA. 1969;209(3):417. doi:10.1001/jama.1969.03160160053020.
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To The Editor:—  Isoproterenol hydrochloride has been in use for approximately eight years as a bronchodilator. It is most commonly administered as an aerosol spray from hand nebulizers. While paradoxical reactions have been noted with isoproterenol hydrochloride,1 to the best of our knowledge no cases of allergy to this drug have been reported. Recently, we had the opportunity to study a case which may represent such allergy.This was the tenth Albany (NY) Veterans Administration Hospital admission for a 48-year-old white man known to have severe emphysema and chronic bronchitis. The patient was told he had "asthma" as a child. Eight years prior to the present admission, he was said to have emphysema. Positive skin reactions to dust and wool had been noted. The present admission was precipitated by a bout of shortness of breath and increased cough of three days' duration. A therapeutic regimen was instituted including intravenously


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