0
ARTICLE |

Antibody Responses in Viral Hepatitis, Type B

Lewellys F. Barker, MD; Michael R. Peterson, MD; N. Raphael Shulman, MD; Roderick Murray, MD
JAMA. 1973;223(9):1005-1008. doi:10.1001/jama.1973.03220090027006.
Text Size: A A A
Published online

Most individuals with viral hepatitis, type B, acquire a serum antigen (hepatitis-B antigen [HB Ag])1 at some time during the incubation period or the acute phase of the disease. Serial sera from 88 patients with viral hepatitis, type B, were examined for antibodies against HB Ag (anti-HB Ag) by passive hemagglutination (PHA) and radioimmunoassay (RIA) methods. Seventy individuals (79.5%) were found to develop serum anti-HB Ag at some time after exposure. Overt occurrences of hepatitis were usually followed by primary-type anti-HB Ag responses. However, early- or secondary-type anti-HB Ag responses were seen in 17 individuals who subsequently developed clinical hepatitis. Most individuals who were resistant to infection after parenteral exposure to materials known to transmit hepatitis had secondary antibody responses. We conclude that primary antibody responses to HB Ag are common after viral hepatitis, type B, and that protective immunity frequently but not invariably follows early exposure to hepatitis-B virus.

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

Figures

Tables

References

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();