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Penicillin Treatment of Streptococcal Pharyngitis

Phillip I. Nieburg, MC
JAMA. 1973;223(7):800-801. doi:10.1001/jama.1973.03220070054025.
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To the Editor.—  The recent report by Colcher and Bass illustrates the positive effect of parental counseling in the treatment of streptococcal pharyngitis with orally administered penicillin. It will serve to reinforce the efforts of those of us who give written instructions and explanations to parents whose children are receiving various treatment regimens.However, the final sentence in the article, favorably comparing oral with parenteral therapy, may be misleading and does not appear justified by the data. All children treated intramuscularly were given 1.2 million units of a mixture of penicillin G procaine and penicillin G benzathine (Bicillin C-R), containing 600,000 units of the latter. As stated in the "Red Book,"2 the recommended dose for children weighing more than 27.1 kg (60 lb) is 900,000 to 1,200,000 units. The Red Book further states "mixtures containing shorter-acting penicillins in addition to penicillin G benzathine have not been shown to be


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