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Toxic Effects of Marihuana

Doris H. Milman, MD
JAMA. 1973;223(7):799. doi:10.1001/jama.1973.03220070053022.
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To the Editor.— Drs. Kolansky and Moore (222:35, 1972) are to be commended for their careful clinical studies of the toxic effects of longterm cannabis use. One would hope that this type of clinical assessment of adverse effects would receive at least as much public attention as uninformed laymen's enthusiastic endorsements.

To the Editor.— The authors make reference in six cases (7-11, 13) to a spontaneous recurrence of the "high" state or feelings of depersonalization in the absence of marihuana usage. These patients were all postulated to have structural biochemical changes. I wonder if the authors have given thought to the significance of this spontaneous recurrence phenomenon. It has also been noted, and, in fact, is considered to be a typical feature of usage of lysergic acid diethylamide (LSD).

To the Editor.— I have observed the recurrence phenomenon in several adolescent patients. Some of these are sporadic rather than heavy or long-term smokers. The experience is very


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