0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Role of Virus in Collagen Diseases

JAMA. 1973;223(5):554. doi:10.1001/jama.1973.03220050054017.
Text Size: A A A
Published online

The etiology of collagen diseases has long interested the world of science. Various theories, including that of autoimmunity, have been proposed. Since 1969 numerous authors have reported the finding of virus-like structures resembling a noncapsulated myxovirus in the tissues of patients with collagen diseases. Gyorkey and his colleagues1,2 called attention to myxovirus-like structures in human collagen diseases, including systemic lupus erythematosus. Others3-10 have reported the finding of a virus resembling nucleoprotein strands, epithelial inclusions, or myxovirus-like viral structures in patients with lupus erythematosus, Sjögren's syndrome, and other collagen diseases.

The most recent report comes from the M. D. Anderson Hospital and Tumor Institute in Houston. Grausz et al11 found cytoplasmic filamentous structures resembling unenveloped nucleocapsids of paramyxovirus or related virus types in vascular endothelial cells of the kidney, skin, and circulating leukocytes from 52 patients with systemic lupus erythematosus, in four patients with systemic sclerosis, in the

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Figures

Tables

References

Letters

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();