Ascorbic Acid and Warfarin

Fred W. Deckert, MD
JAMA. 1973;223(4):440. doi:10.1001/jama.1973.03220040054020.
Text Size: A A A
Published online

To the Editor.—  Since Sigell and Fless (214:2035, 1970) mentioned the possible role of ascorbic acid in anticoagulant therapy, letters by Rosenthal (215:1671, 1971), Hume et al (219:1479, 1972), and Smith et al (221:1166, 1972) have related observations on the interaction of ascorbic acid in patients, as well as in dogs and rabbits. I wish to briefly review some relevant animal studies, especially those performed in guinea pigs (which, like man, cannot biosynthesize ascorbic acid).Karl Paul Link, "father" of the coumarin anticoagulants, and his coworkers had recognized early that various factors could affect the observed response to dicumarol in animals1; of these, the role of ascorbic acid was in a sense one of the most mysterious. In the early 1940s, Baumann et al2 showed that administration of ascorbic acid to rats failed to alter either the extent or the duration of the hypoprothrombinemia produced by dicumarol, but


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours




Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.