We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Medical News

JAMA. 1973;223(4):375-384. doi:10.1001/jama.1973.03220040003002.
Text Size: A A A
Published online


Studies of rejection mechanism start to pay off—slowly  Presensitization remains a serious drawback to successful transplantation of visceral organs. The term applies to a condition wherein graft recipients have preformed cytotoxic circulating antibodies or lymphocytes that are presensitized to the graft antigens; this can lead to either hyperacute or acute rejection.Presensitized lymphocytes, according to Felix T. Rapaport, MD, professor of surgery at New York University School of Medicine, may develop in two ways. The first is as a result of prior tissue damage, as seen in patients with nephritis who may even lose transplants from twins due to recurrence of the disease.The second way is through staphylococcal or streptococcal infections. Dr. Rapaport and colleagues have shown that bacterial membranes (such as those of group A streptococci) and mammalian membranes share certain glycoprotein antigens. Thus activated lymphocytes—or antibodies against the bacterial antigens—may participate in the accelerated rejection of a graft that possesses


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.