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June 2, 1969, Vol 208, No. 9 >
ARTICLE | June 2, 1969

Enzyme Profiles in Pulmonary Infarction

William W. Stead, MD
JAMA. 1969;208(9):1704. doi:10.1001/jama.1969.03160090064023.
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To the Editor:—  I find the article on enzyme profiles by E.L. Coodley, MD, in The Journal (207:1307, 1969) quite confusing. In the body of the paper Dr. Coodley presents evidence that the determination of LDH and its component isoenzymes is of considerable value in helping to distinguish pulmonary from myocardial infarction. Then he mentions that other diseases (pneumonia and heart failure) also cause confusion with which isoenzymes are of less help. But his figures show that most of the elevations of creatine phosphokinase (CPK) and butyrate dehydrogenase (HBD) were associated with myocardial infarction. Then in the abstract at the head of the article he makes the statement: "The use of isoenzymes was of minimal value in differential diagnosis of this condition [pulmonary infarction]." How can this statement be reconciled with the data he gave and the statements he made in the body of the article?Perhaps Dr. Coodley

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