We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Combined Radiation Therapy and Chemotherapy

Maurice Tubiana, MD; Jean-Louis Amiel, MD
JAMA. 1973;223(1):61-64. doi:10.1001/jama.1973.03220010047012.
Text Size: A A A
Published online


Severalrs ago, the value of a combination of radiotherapy and chemotherapy in the treatment of Hodgkin's disease was suggested by several authors,47-49 but was debated by others.50 Both radiotherapy and chemotherapy have since made considerable progress; however, there are still advantages to combining the modalities.

Radiotherapy acts only on the neoplastic tissues that are located within the irradiated zones. For these tissues, the probability of recurrence decreases with the local radiation dose; but, it is never completely impossible. The dose is limited by the risk of local injury, especially in sensitive tissues such as the mediastinum or the spinal cord. The sequelae caused by the irradiation of the liver or of the lungs are so severe that their radical irradiation is practically impossible. Irradiation of the gonads in young patients carries genetic hazards that cannot be neglected.

Extensive chemotherapy has become more and more efficient during the last decade. Aplasia of hematopoietic tissue represents the major limitating factor; in many cases this prevents sterilization of all the


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.