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Article |

Vancomycin-Streptomycin Synergism in Enterococcal Endocarditis

Grant O. Westenfelder, MD; Philip Y. Paterson, MD; Boris E. Reisberg, MD; Gloria M. Carlson
JAMA. 1973;223(1):37-40. doi:10.1001/jama.1973.03220010023005.
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On rare occasion a patient with enterococcal (group D streptococcal) endocarditis will exhibit life-threatening penicillin allergy. The selection of vancomycin hydrochloride and streptomycin as alternate therapy to penicillin-streptomycin under such circumstances is supported by a patient here reported who was cured of enterococcal endocarditis after being treated with vancomycin-streptomycin. In addition, studies upon 18 enterococcal isolates confirm previously reported investigations which indicate that vancomycin and streptomycin in combination exert a synergistic action against a substantial percentage of enterococcal isolates in vitro.


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