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ARTICLE |

Fluid Volume and Albumin Kinetics Occurring With Major Surgery

Robert C. Hoye, MD; Stephen H. Bennett, MD; Glenn W. Geelhoed, MD; Catherine Gorschboth
JAMA. 1972;222(10):1255-1261. doi:10.1001/jama.1972.03210100011003.
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Studies investigating fluid volume dynamics and albumin kinetics in patients undergoing major abdominal surgery indicate that during the operation, marked deficits develop in the total red blood cell volume, plasma volume, extracellular fluid volume, and the total exchangeable albumin pool. A disproportionate deficit in the plasma volume occurring in the course of the operation is believed to be secondary to a functional extracellular fluid volume deficit and abnormal losses of albumin from the intravascular compartment. Deficits in these compartments occurred during the operation in every patient studied. In some patients the plasma volume deficit immediately postoperatively amounted to close to 50% of the volume present when the patient went into the operating room. In the course of a regional node dissection in nine patients studied, a 29% deficit developed in the total body albumin pool.

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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