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ARTICLE |

Bacterial Interference Treatment of Recurrent Furunculosis:  2. Demonstration of the Relationship of Strain to Pathogenicity

Walter G. Strauss, MD; Howard I. Maibach, MD; Henry R. Shinefield, MD
JAMA. 1969;208(5):861-863. doi:10.1001/jama.1969.03160050115019.
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Three patients with furunculosis due to a pathogenic strain of Staphylococcus aureus became free of furuncles after S aureus strain 502A was purposely substituted. Relapse of furunculosis occurred when 502A was lost and the original strain reacquired. Nine other patients lost their furuncles after replacement of a pathogenic strain by 502A. Abscess formation is a strain-related phenomenon in these patients, and disappearance of furuncles was not a chance event but was related to the implantation of strain 502A.

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