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April 28, 1969, Vol 208, No. 4 >

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ARTICLE | April 28, 1969

MEDICAL NEWS

JAMA. 1969;208(4):613-626. doi:10.1001/jama.1969.03160040021003.
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ABSTRACT

Teams Analyze Preoperative Irradiation  A retrospective study of 251 patients with cancer of the larynx and laryngopharynx indicates that the value of preoperative irradiation depends upon the site and severity of the lesion.Three-year survival, local recurrence, neck recurrence, and complications were compared for 103 patients undergoing preoperative irradiation and 179 patients treated by surgery alone. The study was conducted by investigators in the Department of Otolaryngology at Washington University School of Medicine, St. Louis.Hugh F. Biller, MD, assistant professor of otolaryngology, reported that preoperative irradiation:

  • produced a "significant decrease in local recurrence" in a group of Stage III and IV lesions;

  • had no influence on preventing local recurrence in supraglottic and transglottic lesions, but did result in reducing local recurrence and increasing long-term survival in patients with base of the tongue and pyriform sinus lesions; and

  • did not reduce the incidence of neck recurrence. Dr. Biller, Joseph

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