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March 31, 1969, Vol 207, No. 13 >
ARTICLE | March 31, 1969

Adverse Fetal Outcome Following Maternal Rubella After the First Trimes ter of Pregnancy

Janet B. Hardy, MD; George H. McCracken, MD; Mary Ruth Gilkeson; John L. Sever, MD
JAMA. 1969;207(13):2414-2420. doi:10.1001/jama.1969.03150260074010.
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Of the 24 women with clinical and laboratory evidence of rubella between the 14th and 31st weeks of pregnancy, two experienced fetal loss and 22 were delivered of liveborn infants who survived. Rubella virus was recovered from the products of conception in the instances of fetal loss, and from the throats of two and the placenta of another of the 19 live-born tested. Seven of the live-born children are normal, one had an elevated serum IgM level at birth, and none of the seven have detectable rubella antibody after six months of age. Fifteen of the live-born children are suspected to be abnormal; ten of these have problems in communication. Of the 15, six have had elevated serum IgM levels and ten have had detectable levels of rubella antibody after 6 months of age.

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