0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Medical News

JAMA. 1976;235(14):1409-1418. doi:10.1001/jama.1976.03260400003001.
Text Size: A A A
Published online

ABSTRACT

Prophylactic cancer chemotherapy may have first trials soon  The first clinical trials in cancer chemoprevention could begin within a year under the auspices of the National Cancer Institute (NCI), in Bethesda, Md.The idea of cancer chemoprevention is to use pharmacologic means to stop or reverse preneoplastic changes in tissue before the ultimate progression to tumor formation becomes irreversible.The principal chemical to be tested could be 13-cis-retinoic acid, a synthetic analog of vitamin A, that would be administered to persons at high risk of cancer."I think there are people in the United States at sufficiently high risk of cancer that one could justifiably consider the possibility of putting them on a regimen of 13-cis-retinoic acid on a prophylactic basis," says Michael B. Sporn, MD, chief of the Lung Cancer Branch at NCI. Among the possible candidates for such treatment are asbestos workers and

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();